There's a ton to see and do in Florence. Everybody's different, but below are some places to help you get started on building an itinerary for yourself.
NYT - 36 hours in Florence Itinerary
Rick Steves Florence Itinerary
The Uffizi Gallery
6 Piazzale degli Uffizi, Firenze, Toscana 50122, Italy
This place gets mega crowded!
Make sure to make reservations as soon as you book your accommodations (months in advance)!
The Accademia Gallery
58 Via Ricasoli, Firenze, Toscana 50129, Italy
Same as the Uffizi, this place gets mega crowded!
Make sure to make reservations as soon as you book your accommodations (months in advance)!
Cathedral of Santa Maria del Fiore
Piazza del Duomo, Firenze, Toscana 50122, Italy
Seeing the cathedral (more commonly known as "the Duomo") is free -- however, if you want to go up the dome or the campanile (the tower), into the baptistry, or into the museums, you'll need tickets. Lines for entry are long, but they move.