Flight
The Reno, NV airport is the most convenient to Lake Tahoe. It's approximately 45 minutes from the airport to the West Shore. While Uber and/or Lyft are available in the Tahoe area, their availability after Labor Day can be limited. Renting a car will give you the best opportunity to explore everything the area has to offer.
House Or Rental
Mother of the Bride, Margot Woodward, put together an excellent list of potential accommodations. Hotels, AirBnB and VRBO (along with other rental sites) are all phenomenal options.