This little town outside of Avignon is nicknamed the Venice of the region. The river runs throughout the town and there is even a floating market. Important artists including Braque, Char, and Picasso lived here. Today it is famous for its antiquaries shops and Roman ruins.
Gorges de la Nesque is a spectacular canyon with hiking options. From the village of Monieux, you can take a short walk to visit a troglodyte chapel near the river.
Vaison-la-Romaine is one of the most important Roman sites in France, featuring medieval old city and a castle.
Gordes is a small, beautiful medieval city well worth a visit. Close to Gordes stands one of the most famous French Cistercian abbeys: Senanques, which is still occupied by monks and open to visitors.
The city of Avignon is beautiful, historic, and fun. This makes it well-worth a visit, especially if you are passing through anyway.