House Or Rental
Airbnb is a popular choice when coming to San Diego instead of a hotel. Neighborhoods to look into are La Jolla, Mission Beach, Pacific beach, or Point Loma.
Flight
San Diego airport is the closet to fly into. It is about 15 minutes to Mission Beach from there.
Rental Car
Uber and Lyft are very easy to get around in San Diego. If you have kids or other activities planned you may opt to have a rental car to get around.
Hotel
A couple of hotels in the area: Bahia Resort Hotel (wedding location) Paradise Point Resort & Spa Hyatt Regency Mission Beach San Diego Mission Bay Resort